Table 2.

Effect of ablating the mitochondrial fusion proteins in the adult heart

Study	Fusion protein	Murine model	Mitochondrial morphology (TEM)	MPTP susceptibility	IRI sensitivity	Other effect
Papanicolaou et al., 2012a	MFN1	Cardiac knockout (KO)	Smaller	Reduced	Reduced	No phenotype
Papanicolaou et al., 2011	MFN2	Cardiac KO	Pleomorphic, larger	Reduced	Reduced	Modest LV hypertrophy, mild LV impairment
Wang et al., 2012	MFN2	Cardiac KO	Pleomorphic, larger	Not tested	Increased	Impaired mito function and autophagy
Chen et al., 2011	MFN1/MFN2	Cardiac KO	Smaller	No change	Not known	Impaired mito function
Piquereau et al., 2012	OPA1	Whole body OPA1 +/−	Pleomorphic larger	Reduced	Not known