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Drp1 deficiency does not attenuate rapid, ABT-737-induced caspase-dependent cell death. WT or Drp1 KO MEF cells were treated with vehicle control (con), ABT-737 (0.5, 1.0 or 10 μM), Q-VD (20 μM), ABT-737 (10 μM) + Q-VD (20 μM) or saponin (100 μg·mL−1) for 4 h. Cell death is expressed as percentage release of the cytoplasmic enzyme LDH. Results are mean ± SEM of three independent experiments performed in triplicate.
