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(A) Proposed model of the 1:1 interaction of SS-31 with CL shows favourable overlap of opposite electrostatic charges and hydrophobic regions. (B) Schematic diagram of mitochondrial dysfunction during early post-ischaemia. Unfolding of cyt c due to hydrophobic interaction with CL on the outer leaflet of the inner membrane prevents electron transport through complex III and IV. SS-31 localizes to CL, stabilizes cyt c in its folded conformation and restores electron transport.
