. Author manuscript; available in PMC: 2015 Apr 30.

Published in final edited form as: Stat Med. 2013 Dec 16;33(9):1600–1618. doi: 10.1002/sim.6067

Table 2.

Powers and Type I Errors at Interim Analyses and Final Analysis for the Sequential Meta-Design with n₉ = 3250

	a₀	(φ₀₁, φ₀₂)	IA1^*	IA2^*	IA1 ⇒ Final	IA2 ⇒ Final	Overall
Power	0	(0.96, 0.97)	0.5181	0	0.2580	0.0008	0.7769
		(0.97, 0.97)	0.4681	0.0001	0.2996	0.0017	0.7695
		(0.98, 0.96)	0.4038	0.0006	0.3886	0.0038	0.7968
		(0.98, 0.97)	0.4023	0.0003	0.3553	0.0029	0.7608
		(0.99, 0.96)	0.2997	0.0021	0.4803	0.0094	0.7915
	0.0150	(0.96, 0.97)	0.5758	0	0.2434	0.0004	0.8196
		(0.97, 0.97)	0.5251	0	0.2853	0.0005	0.8109
		(0.98, 0.96)	0.4557	0.0003	0.3749	0.0024	0.8333
		(0.98, 0.97)	0.4557	0.0002	0.3460	0.0015	0.8034
		(0.99, 0.96)	0.3514	0.0010	0.4682	0.0059	0.8265
	0.0215	(0.96, 0.97)	0.5849	0	0.2414	0.0004	0.8267
		(0.97, 0.97)	0.5373	0	0.2816	0.0004	0.8193
		(0.98, 0.96)	0.4654	0.0003	0.3715	0.0022	0.8394
		(0.98, 0.97)	0.4659	0.0002	0.3422	0.0018	0.8101
		(0.99, 0.96)	0.3583	0.0008	0.4696	0.0055	0.8342

Type I Error	0	(0.96, 0.97)	0.0390	0	0.0174	0.0001	0.0565
		(0.97, 0.97)	0.0289	0	0.0188	0.0001	0.0478
		(0.98, 0.96)	0.0190	0	0.0293	0.0004	0.0487
		(0.98, 0.97)	0.0185	0	0.0210	0.0003	0.0398
		(0.99, 0.96)	0.0094	0	0.0324	0.0008	0.0426
	0.0150	(0.96, 0.97)	0.0466	0	0.0195	0	0.0661
		(0.97, 0.97)	0.0368	0	0.0215	0.0001	0.0584
		(0.98, 0.96)	0.0238	0	0.0331	0.0003	0.0572
		(0.98, 0.97)	0.0241	0	0.0235	0.0002	0.0478
		(0.99, 0.96)	0.0117	0	0.0389	0.0006	0.0512
	0.0215	(0.96, 0.97)	0.0499	0	0.0206	0	0.0705
		(0.97, 0.97)	0.0386	0	0.0218	0	0.0604
		(0.98, 0.96)	0.0257	0	0.0347	0.0002	0.0606
		(0.98, 0.97)	0.0255	0	0.0246	0.0001	0.0502
		(0.99, 0.96)	0.0127	0.0001	0.0403	0.0005	0.0536

IA1 and IA2 denote the first and second interim analyses, respectively.