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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Transl Res. 2013 Oct 25;163(4):286–295. doi: 10.1016/j.trsl.2013.10.005

Figure 3. Kidney regeneration by the microvesicles released by mesenchymal stem cells and endothelial progenitor cells.

Figure 3

(A) Microvesicles derived from mesenchymal stem cells (MSCs) inhibit apoptosis and stimulate proliferation of renal tubular epithelial cells. Microarray analysis of microvesicle RNA detected 239 mRNA species, including species with the functions described at the right.

(B) Microvesicles released from endothelial progenitor cells (EPCs) induce quiescent endothelial cells to reenter the cell cycle and form blood vessels. In addition to mRNA species, miRNAs are also transferred by the microvesicles.