Table 3.
Geometric mean (95% CI) of angiogenesis biomarkers at baseline and 12 month, stratified by intervention arm, adjusted for BMI and baseline biomarker levels
| Stretching control | Exercise Intervention | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BASELINE | 12-MONTH | Change (%) |
BASELINE | 12-MONTH | Change (%) |
P* | |||||||||
| N | Mean | 95% CI | N | Mean | 95% CI | N | Mean | 95% CI | N | Mean | 95% CI | ||||
|
VEGF (pg/mL) |
84 | 418.3 | (367–479) | 82 | 419 | 369–475 | −0.7 (−0.2) | 85 | 325 | 286–370 | 83 | 320.8 | 281–366 | −4.2 (−1.3) | 0.86 |
|
PEDF (ug/mL) |
84 | 11.4 | (10.9–12.0) | 82 | 11.8 | 11.2–12.4 | 0.3 (3.0) | 85 | 11.6 | 11.1–12.1 | 83 | 11.2 | 10.7–11.7 | −0.4 (−3.7) | 0.009 |
|
PAI-1 (ng/mL) |
80 | 5.4 | (4.8–6.1) | 80 | 5.6 | 4.9–6.3 | 0.2 (2.9) | 84 | 5.1 | 4.5–5.7 | 81 | 4.8 | 4.3–5.4 | −0.2 (−4.4) | 0.18 |
|
OPN (ng/mL) |
80 | 57.9 | (54.8–61.2) | 80 | 57.2 | 54.4–60.2 | −0.7 (−1.2) | 84 | 59.3 | 56.5–62.2 | 81 | 57.5 | 54.8–60.3 | −1.8 (−3.0) | 0.47 |
*
P value: GEE model, testing the difference in change from baseline to 12 month between Control group and Exercise group, adjusted for BMI and baseline biomarker level.