Table 3.
Genotyping and allele frequency of ORAI1 gene in chronic kidney disease patients.
| Genotype | Late stage (%) (n = 453) |
Early stage (%) (n = 126) |
Allele | Late stage (%) (n = 453) |
Early stage (%) (n = 126) |
Genotype P value |
Dominant P value |
Recessive P value |
Allelic P value |
|
|---|---|---|---|---|---|---|---|---|---|---|
| rs12320939 | TT | 94 (20.8) | 28 (22.4) | T | 424 (47.0) | 115 (46.0) | 0.6482 | 0.4482 | 0.7955 | 0.7363 |
| TG | 236 (52.3) | 59 (47.2) | G | 478 (53.0) | 135 (54.0) | |||||
| GG | 121 (26.8) | 38 (30.4) | ||||||||
|
| ||||||||||
| rs12313273 | CC | 36 (8.0) | 14 (11.3) | C | 271 (30.0) | 74 (29.8) | 0.3780 | 0.5522 | 0.3148 | 0.9939 |
| CT | 199 (44.0) | 46 (37.1) | T | 633 (70.0) | 174 (70.2) | |||||
| TT | 217 (48.0) | 64 (51.6) | ||||||||
|
| ||||||||||
| rs7135617 | TT | 80 (17.7) | 18 (14.5) | T | 378 (41.9) | 103 (41.5) | 0.4551 | 0.6285 | 0.3425 | 0.8567 |
| TG | 218 (48.3) | 67 (54.0) | G | 524 (58.1) | 145 (58.5) | |||||
| GG | 153 (33.9) | 39 (31.5) | ||||||||
|
| ||||||||||
| rs6486795 | CC | 53 (11.8) | 18 (14.2) | C | 323 (35.8) | 90 (35.7) | 0.5856 | 0.6638 | 0.4536 | 0.9574 |
| CT | 217 (48.1) | 54 (42.9) | T | 579 (64.2) | 162 (64.3) | |||||
| TT | 181 (40.1) | 54 (42.9) | ||||||||
|
| ||||||||||
| rs712853 | CC | 46 (10.2) | 10 (8.0) | C | 274 (30.4) | 76 (30.4) | 0.6072 | 0.6717 | 0.4667 | 0.9998 |
| CT | 182 (40.4) | 56 (44.8) | T | 626 (69.6) | 174 (69.6) | |||||
| TT | 222 (49.3) | 59 (47.2) | ||||||||
Late stage: eGFR <45, early stage: eGFR ≥45.
All P values had been adjusted by age using logistic regression.