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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Clin Sports Med. 2014 Jan 10;33(2):199–220. doi: 10.1016/j.csm.2013.11.004

Figure 2. STRING interaction network.

Figure 2

Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) is a database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations. STRING quantitatively integrates interaction data. The database currently covers 5,214,234 proteins from 1133 organisms (104). The interaction network was generated by seeding with genes identified through GWAS (see Table 3). Additional interacting proteins were identified through STRINGS and are included in the network as likely candidates for contributing roles in OCD. Blue lines connecting each node are weighted for confidence of interaction, based on peer-reviewed, published information. More data exists to support an interaction between those nodes connected by the heavier blue lines. Genes cluster into 1) a collagen cluster, 2) a laminin cluster, 3) a cell signaling cluster, 4) a matrix turnover cluster, 5) a posttranslational modification cluster. Each of these clusters is linked by multiple connections.