Table 1.
Comparison of published reports detailing characteristics of patients with brain metastases from primary osteosarcoma.
| Case author | Age, sex | Primary site | Primary treatment | IB Mo | Metastatic site | Metastatic treatment | OS Mo | Special aspects |
|---|---|---|---|---|---|---|---|---|
| Rabah et al., 2013 [13] | 10 F | Right humerus | (None) | 0a | Right frontal lobe | Chemo, WBRT | 14 | Cerebral metastasis on presentation |
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| Onodera et al., 2012 [14] | 14 F | Left femur | Surgery, chemo | 12 | Right parietal lobe | SR | NR | No active pulmonary metastasis |
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| Chou et al., 2011 [4] |
N = 5 15–58, M (4) |
NR | NR | NR | Single cerebrum (3); multiple (2) | SR + RT | D | |
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| Flannery et al., 2010 [15] |
N = 3 17–37, M (3) |
Pelvis, femur, humerus | Chemo | NR | 1 single, 2 multiple | GKSRS | 36–84 | Gamma knife radiosurgery as therapy |
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| Salvati et al., 2010, 1998 [2, 9] |
N = 10 11–60, M (5) |
Femur, tibia | NR | 0–110 | Frontal (5), multiple (3), parietal, temporal | SR + WBRT | NR | |
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| Niazi et al., 2009 [20] | 16 M | Right femur | (None) | 0a | Left cerebellum | SR | 6 days | Posterior fossa hemorrhage on presentation |
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| Kebudi et al., 2005 [3] |
N = 5 12–16, M (3) |
NR | NR | 3–27 | Single (3), multiple (2) |
None (2); RT + chemo (3) |
1–6 | Literature review included in original study |
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| Yonemoto et al., 2003 [18] | 14 F | Right femur | SR + chemo | 26 | Tumor infiltration outside the bone cortex | SR + WBRT | Alive at 72 | N/a |
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| Paulino et al., 2003 [17] |
N = 5 11–19, M (4) |
Femur (2), humerus, tibia, scapula | NR | 10–48 | Frontal (3), occipital (1), multiple (1) | SR, chemo, WBRT, None (2) | 1–10 | |
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| Weil et al., 2005 [21] | 26 M | Right tibia | Chemo + SR | 36 | Skull and brain metastasis | SR | 4 | Patient refused chemo or RT for brain met treatment |
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| Bouffet et al., 1997 [16] |
N = 3 9-17, M |
NR | NR | 12–15 | Supratentorial (2) | None RT (2) |
2–4 | |
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| Wroński et al., 1995 [5] |
N = 5 7–26, M (2) |
Femur (3), maxilla humerus | NR | 18–63 | Temporal, parietal/occipital (3), posterior fossa | SR | 2.4–13 | WBRT was given to select patients (unspecified) |
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| Chang et al., 1994 [22] | 20 M | Bilateral femur | (None) | 0a | Right frontal lobe | SR + RT | 5 | Early metastasis, multifocal |
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| Marina et al., 1993 [19] | 3 M | Left humerus | SR, chemo | 4 | Temporal and left parietal | Chemo | Alive at 108 | Additional review of 13 patients |
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| Wexler et al., 1993 [23] | 10 F | Right femur | SR, chemo | 51 | Left parietal and occipital | SR, WBRT | Alive at 120 | N/a |
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| Niedeggen et al., 1990 [24] | 7 M | Left femur | SR, chemo | 76 | Right parietal lobe | SR, RT | Alive at 13 | Histological findings included |
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| Baram et al., 1988 [25] |
N = 5 8–15, M (2) |
NR | Chemo ± SR | 2–46 | Frontal (2), multiple (1), NR (2) | Chemo ± SR | D | Incidence, clinical, and radiological findings and management |
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| Lewis, 1988 [26] | 15 F | Right humerus | Local radiotherapy | 0c | Left frontal lobe, left corpus callosum | Chemo | 0 | Brain lesions discovered upon autopsy |
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| Ozarda et al., 1983 [27] | 23 M | Right femur | NR | 8 | Right occipital lobe | Chemo + RT | NR | Bone scintigraphy usage |
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| Danziger et al., 1979 [28] |
N = 3 18–20, F (3) |
Right femur (3) | SR, chemo, RT | 6–24 | Temporal/occipital, frontoparietal, parietal | Chemo + RT SR, none |
D (2), NR | |
IB: interval to brain metastasis (mo); OS: overall survival in months; M: male; F: female; chemo: chemotherapy; SR: surgical resection; GKSRS: Gamma knife stereotactic radiosurgery. WBRT: whole brain radiotherapy; RT: radiotherapy; D: death prior to treatment; NR: not reported; abrain metastasis at initial presentation; balive at last follow-up without recurrence; cbrain metastasis at autopsy.