Table 4.
Comparison of published reports detailing characteristics of patients with brain metastases from fibroblastic and fibrohistiocytic tumors.
| Case author | Age, sex | Tumor type; primary site | Primary treatment | IB Mo | Metastatic site | Metastatic treatment | OS Mo | Special aspects/ Bone versus soft tissue origin |
|---|---|---|---|---|---|---|---|---|
| Wu et al., 2012 [59] | 32 F | MFH; maxillary sinus | SR (radical); RT | 24 | Right parietal | SR; WBRT | 25 | Origin: softtissue |
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| Graber et al., 2011 [60] | 56 M | MFH; aorta | RT; chemo | 0a | Multiple | Biopsy | ? | Cystic brain lesion; mimics neurocysticercosis Origin: softtissue (aorta) |
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| Louis et al., 2007 [58] | 38 M | MFH; mandible | SR; RT | 12 | Extensive, unspecifieda | None | 12 | MFH associated w/a Marjolin's ulcer Origin: bone |
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| Kousar et al., 2009 [70] | 20 F | AFS; mandible | SR; RT | 6 | Multiple | None | 15 | Origin: odontic = bone |
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| Hoshi et al., 2008 [63] | 45 M | MFH; forearm | SR; RT; chemo | 48 | Multiple, parietal, and occipital | Chemo, WBRT | 60 | Previous lung/bone metastasis at 3 yrs; SC metastasis at 5 yrs Origin: softtissue |
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| Erguvan-Önal et al., 2004 [71] | 45 F | FS; thigh | SR; RT | 2 | Right frontal | SR | 7 | Epitheloid transformation; Origin: softtissue |
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| Rogers and Whelan, 2000 [64] |
N = 4 40–54, M (2) |
MFH; humerus, femur, knee, pelvis | Chemo; RT | 4–148 | Multiple (2), single (2) | RT (2), none (2) | 7–153 | Previous systemic metastasis in all Origin: bone |
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| Ogose et al., 1999 [33] |
N = 5 40–66, M (2) |
Thigh (3), back | NR | 0–10 | Frontal (3), parietal, temporal | None (2), SR (2) | 0.5–16 | Origin: unknown |
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| Salvati et al., 2010 [2] |
N = 2 21–30, M |
MFH; heart, heart | RT, chemo | 19–21 | Frontal | SR | 9–11 | Origin: soft tissuee |
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| I. A. Auer and R. N. Auer, 1998 [72] | 43 M | DFS; abdomen | NR | 72 | Tempro-parietal | SR | 144 | Brain recurrence at 144; prior skin, lung metastasis |
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| Kim et al., 1997 [69] | 18 F | MFS; heart | SR, RT, chemo | 24 | Occipital, cerebellum | SR, WBRT | 50 | Origin: softtissue |
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| Jeffery and Ford, 1995 [67] | 67 F | FS; abdominal wall | SR | 60 | Right parietal lobe | None | 61 | ICH; previous bone metastasis; origin: sof-tissue |
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| Onoda et al., 1990 [73] | 45 M | DFS; upper arm | SR | 76 | Multiple | none | 84 | Lungs, skin |
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| Wroński et al., 1995 [5] |
N = 3 28–67, M (2) |
MFH; scalp, thigh, pul.a. | NR | 3–27 | Occipital, parietal, posterior fossa | SR | 10.2b–65b | Lungs |
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| Bindal et al., 1994 [38] |
N = 3 25–40, M (2) |
MFH; trunk, heart, shoulder | 12–2218 | Right parietal, multiple (2) | SR, WBRT | 2.3b–11.8b | Prev lungs | |
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| Lewis, 1988 [66] | 36–53, M | DFS; clavicular; MFH, scapular | SR; RT, chemo | 36–312 | Multiple | SR; nonec | 313, LTF | Origin: softtissue |
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| Takamiya et al., 1986 [65] | 43 M | FS; pectoralis major | SR | 1 | Right frontoparietal | SR, RT, WBRT | Alive at 13 | Origin: sof-tissue |
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| Zucker et al., 1978 [61] | 42 F | FS; liver? | None | 24 | Pons | none | 24 | Origin: softtissue |
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| Dal Canto and Valsamis, 1973 [62] | 60 F | FS; renal capsule | None | 0 | Pons | None | 0 | Origin: softtissue |
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| Gercovich et al., 1975 [42] |
N = 2 31–52 M |
FS; lip, retroperitoneal | Chemo | 3–55 | Frontal, parietal | NR | NR | Origin: softtissue |
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| Ho, 1979 [68] | 70 F | FS; thigh | SR (partial) | 12 | Leptomeninges, cortical | Nonec | NR | Origin: softtissue |
AFS: ameloblastic fibrosarcoma; FS: fibrosarcoma; DFS: dermatofibrosarcoma; IB: interval to brain metastasis (mo); OS: overall survival in months; M: male; F: female; chemo: chemotherapy; GKSRS: Gamma knife stereotactic radiosurgery; MFS: myxofibrosarcoma; ICH: intracerebral hemorrhage on presentation; SR: surgical resection; WBRT: whole brain radiotherapy; RT: radiotherapy; D: death prior to treatment; LTF: lost to follow-up; MFH: malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma); NR: not reported.
aBrain metastasis diagnosed at presentation; bsurvival after craniotomy; cbrain metastasis reported at autopsy.