Table 3.
Adjusted Association of Baseline Sociodemographic and Clinical Characteristics With Clinical Trial Enrollment After Propensity Weighting; N = 352a
| Enrollment in a Clinical Trial at Baseline | |||
|---|---|---|---|
| Patient Characteristic | In a Trial n=37 n (%) |
Not a in Trial n=315 n (%) |
P-value |
| Demographic Characteristics | |||
| Age, yrs, mean±SD | 55.94±25.04 | 55.94±8.48 | 1.000 |
| Male gender | 83.43 (50.00%) | 83.43 (50.00%) | 1.000 |
| Income >$31,000 | 67.23 (45.76%) | 79.70 (54.24%) | 0.178 |
| Married | 116.2 (50.01%) | 116.1 (49.99%) | 0.994 |
| Health Insurance | 157.0 (50.00%) | 157.0 (50.00%) | 1.000 |
| Education, yrs, mean±SD | 13.59±7.60 | 13.9±2.57 | 1.000 |
| Race/Ethnicity | |||
| White | 135.1 (50.00%) | 135.1 (50.00%) | 1.000 |
| Black | 19.16 (50.00%) | 19.16 (50.00%) | 1.000 |
| Hispanic | 14.25 (50.00%) | 14.25 (50.00%) | 1.000 |
| Asian | 7.45 (60.43%) | 4.88 (39.57%) | 0.456 |
| Religion | |||
| Catholic | 65.83 (50.00%) | 63.83 (50.00%) | 1.000 |
| Protestant | 21.37 (50.00%) | 21.37 (50.00%) | 1.000 |
| Baptist | 17.17 (46.15%) | 20.04 (53.85%) | 0.619 |
| Pentecostal | 3.89 (61.78%) | 2.41 (38.22%) | 0.551 |
| Jewish | 22.21 (50.00%) | 22.21 (50.00%) | 1.000 |
| Muslim | 5.45 (58.33%) | 3.89 (41.67%) | 0.606 |
| None | 8.04 (38.52%) | 12.83 (61.48%) | 0.279 |
| Recruitment Site | |||
| Yale Cancer Center | 81.34 (50.00%) | 81.34 (50.00%) | 1.000 |
| Veterans Affairs CCC | 0.00 (0.00%) | 3.48 (100.00%) | 0.061 |
| Simmons Cancer Center | 20.36 (50.43%) | 20.01 (49.57%) | 0.954 |
| Parkland Hospital | 29.36 (50.00%) | 29.36 (50.00%) | 1.000 |
| DFCI/MGH | 4.57 (31.01%) | 10.18 (68.99%) | 0.136 |
| New Hampshire Oncology | 18.78 (50.00%) | 18.78 (50.00%) | 1.000 |
| Clinical Characteristics | |||
| Cancer Type | |||
| Lung | 20.39 (50.00%) | 20.39 (50.00%) | 1.000 |
| Pancreatic | 33.41 (50.00%) | 33.41 (50.00%) | 1.000 |
| Colon | 19.66 (50.83%) | 19.02 (49.17%) | 0.912 |
| Gastric | 8.31 (50.00%) | 8.31 (50.00%) | 1.000 |
| Esophageal | 9.91 (50.00%) | 9.91 (50.00%) | 1.000 |
| Biliary | 0.00 (0.00%) | 4.64 (100.0%) | 0.030 |
| Brain | 8.47 (50.00%) | 8.47 (50.00%) | 1.000 |
| Performance status, mean ± SD | |||
| Karnofsky Score | 68.95±41.09 | 68.77±13.79 | 0.925 |
| ECOG Score | 1.52±2.06 | 1.52±0.75 | 0.979 |
| Charlson Comorbidity Index | 7.58±5.29 | 7.58±1.93 | 1.000 |
| McGill QOL, mean ± SD | |||
| Sum Score | 7.05±2.34 | 7.05±1.16 | 1.000 |
| Physical function | 5.89±4.23 | 5.53±2.06 | 0.162 |
| Symptoms | 5.86±3.40 | 5.86±1.64 | 1.000 |
| Psychological | 7.57±4.75 | 7.78±1.65 | 0.387 |
| Support | 8.51±3.37 | 8.71±1.37 | 0.253 |
| Psychosocial Characteristics | |||
| Brief COPE, mean ± SD | |||
| Emotional support-based coping | 2.00±1.34 | 1.86±0.67 | 0.095 |
| Active coping | 2.47±1.42 | 2.55±0.46 | 0.250 |
| Behavioral disengagement | 0.20±0.99 | 0.15±0.28 | 0.332 |
| RCOPE, mean ± SD | |||
| Positive RCOPE | 10.09±15.42 | 9.55±4.87 | 0.449 |
| Negative RCOPE | 1.25±5.95 | 1.49±2.29 | 0.452 |
| EOL Care Preferences and Advance Care Planning | |||
| Terminal illness acknowledgement | 59.82 (52.86%) | 53.34 (47.17%) | 0.459 |
| Desires prognostic information | 94.76 (48.68%) | 99.92 (51.32%) | 0.580 |
| Prior EOL discussion | 39.63 (50.00%) | 39.63 (50.00%) | 1.000 |
| Preferences for EOL care | |||
| Values life-extension over comfort | 54.09 (44.44%) | 67.62 (55.56%) | 0.129 |
| Against ICU death | 58.30 (49.30%) | 59.95 (50.70%) | 0.853 |
| Prefer ventilator | 60.07 (54.48%) | 50.18 (45.52%) | 0.256 |
| Prefer chemotherapy | 156.5 (51.30%) | 148.5 (48.70%) | 0.214 |
| Prefer feeding tube | 67.50 (49.35%) | 69.29 (50.65%) | 0.845 |
| DNR order | 69.83 (50.97%) | 67.19 (49.03%) | 0.772 |
| Living will & health care proxy | 100.5 (50.28%) | 99.33 (49.72%) | 0.904 |
a
N=352, decreased from 358 because of six patients with missing propensity score data.