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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Biol Psychiatry. 2013 Oct 5;76(2):120–127. doi: 10.1016/j.biopsych.2013.09.026

Figure 2. Overexpressing Nrg1-ntfβ in mice activates the Nrg1-ErbB pathway.

Figure 2

(A) Transgenic mice at postnatal day 10 (P10) and 30 (P30) were examined for changes in the indicated proteins. Increased phosphorylation of Akt (p-Akt) and Erk (p-Erk) was observed in Tg-N1β/T compared to control Tg-N1β mice. There was a significant increase in levels of the myelin protein PLP, while MBP levels were slightly elevated in Tg-N1β/T mice of both ages. (B). Bar graphs show normalized changes in p-Akt/Akt and p-Erk/Erk ratios, as well as MBP and PLP levels (n=3 per group; *:p<0.05, **:p<0.01, ***:p<0.001, Student’s t-test).