Skip to main content
. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Biol Psychiatry. 2013 Oct 5;76(2):120–127. doi: 10.1016/j.biopsych.2013.09.026

Figure 6. Tg-N1β/T mice showed hyperactivity in an open field test.

Figure 6

(A) Prior to injection with MK-801, a noncompetitive antagonist of the NMDA receptor, all four groups of mice (with or without Dox treatment for one month) showed no significant differences in exploratory activity in the open field. After the injection, all groups of mice became hyperactive compared to the time before the injection. Tg-N1β/T mice showed significantly higher levels of exploratory activity compared to the control groups. (B) Detailed time series plots show that hyperactivity was significant beginning at 45 min after the injection and reached a peak at 75 min after the injection. Statistics were analyzed by one-way ANOVA followed by Tukey’s post hoc test (n=10 per group; *:p<0.05, **:p<0.01, ***:p<0.001).