Table 2.
Summarizing the possible treatment options for ED in elderly patients.
| Drug | Dose | t 1/2 (h) | Frequency | Advantages | Side effects |
|---|---|---|---|---|---|
| Sildenafil Tadalafil Vardenafil Avanafil |
25, 50*, 100 mg 2.5, 5, 10, 20 mg 2.5, 5, 10*, 20 mg 50, 100, 200 mg |
4.6 17–21 4-5 5–10 |
On demand or daily |
Safe; available on demand as well as continuous low dose (vardenafil 2.5 mg, tadalafil 2.5 mg) |
Headache, myalgia, back pain, blurred vision, facial flushing, nasal congestion, dizziness |
|
| |||||
| Yohimbine | 5–15 mg | 0.25–2.5 | Three times daily |
Natural product | Hypertension, tachycardia, anxiety |
|
| |||||
| Vacuum constriction device | / | / | On demand | Effective in 90% of patients; not expensive | Skin necrosis, pai006E, cold penis, unnatural erection |
|
| |||||
| Papaverine PGE1 Phentolamine |
30–110 mg 5–40 μg 1.25–2 mg |
1.5–2.5 0.30 0.19 |
On demand | Broad efficacy, safety, and effecacy in neurogenic ED | Priapism, pain, penile fibrosis, injection training requested |
|
| |||||
| MUSE | 125, 250, 500, 1,000 μg |
0.30 | On demand | No injections needed | Hypotension, pain, urethral burning, syncope, vaginal irritation in the partner |
|
| |||||
| Penile prosthesis | / | / | On demand | High satisfation rates | Irreversible, infection, erectile lenght loss, autoinflation |
t 1/2: plasma half-life; h: hours; *also available in orodispersable formulation (supralingual).