Table 3.
Cox regression analysis of factors associated with time from surgery to commencement of adjuvant chemotherapy.
| Univariate analysis | Multivariate analysis (n = 159) | |||||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | χ 2 | P | Hazard ratio (95% CI) | χ 2 | P | |
| Age | 0.993 (0.978 to 1.007) | 0.973 | 0.324 | |||
| Gender (F) | 1.310 (0.937 to 1.832) | 2.500 | 0.114 | |||
| BMI | 0.991 (0.961 to 1.023) | 0.292 | 0.589 | |||
| Comorbidity (Y) | 1.083 (0.789 to 1.488) | 0.247 | 0.619 | |||
| Neoadjuvant therapy (Y) | 0.889 (0.625 to 1.265) | 0.425 | 0.514 | |||
| Laparoscopic procedure (Y) | 1.337 (0.906 to 1.973) | 2.141 | 0.143 | |||
| Stoma (Y) | 0.757 (0.555 to 1.031) | 3.115 | 0.078 | 0.704 (0.512 to 0.970) | 4.613 | 0.032 |
| Tumour size | 1.002 (0.994 to 1.010) | 0.180 | 0.672 | |||
| Differentiation (poor versus well/moderate) | 1.201 (0.679 to 2.122) | 0.396 | 0.529 | |||
| T stage | 1.009 (0.863 to 1.179) | 0.013 | 0.911 | |||
| N stage | 0.940 (0.680 to 1.299) | 0.141 | 0.707 | |||
| Lymph node ratio | 0.494 (0.215 to 1.131) | 2.785 | 0.095 | 0.408 (0.168 to 0.992) | 3.915 | 0.048 |
| Resection margin status (+) | 0.917 (0.546 to 1.541) | 0.107 | 0.744 | |||
| Vascular invasion (+) | 1.151 (0.816 to 1.623) | 0.645 | 0.422 | |||
| Anastomotic leak (Y) | 0.304 (0.123 to 0.749) | 6.701 | 0.010 | 0.352 (0.140 to 0.887) | 4.907 | 0.027 |
| Preoperative haemoglobin | 1.006 (0.915 to 1.105) | 0.013 | 0.908 | |||
| Preoperative platelets | 1.000 (0.999 to 1.002) | 0.613 | 0.434 | |||
| Preoperative neutrophils | 0.977 (0.915 to 1.042) | 0.518 | 0.472 | |||
| Preoperative lymphocytes | 0.966 (0.824 to 1.131) | 0.187 | 0.666 | |||
| Preoperative C-reactive protein | 0.998 (0.994 to 1.001) | 1.751 | 0.186 | |||
| Preoperative albumin | 1.036 (1.007 to 1.067) | 5.933 | 0.015 | 1.034 (1.004 to 1.065) | 4.916 | 0.027 |
| Tumour site (colon versus rectum) | 1.092 (0.802 to 1.487) | 0.311 | 0.577 | |||
| Emergency (Y) | 0.755 (0.426 to 1.339) | 0.925 | 0.336 | |||