Fig. 4.
Silencing STAT3 and JNK repressed mdig expression. A. BEAS-2B cells were transfected with 50 nM control siRNA (siCtrl), or STAT3 specific siRNA (siSTAT3) and cultured for 24 h. Cells were cultured in the presence of 20 μM As3+ for an additional 2 h. The levels of STAT3 activation, mdig protein, JNK and Akt activation were determined by Westernblotting. B. Silencing JNK2, but not JNK1, reduced the levels of basal and As3+-induced mdig. Cell transfection with siRNA and treatment are the same as in A.