Skip to main content
. Author manuscript; available in PMC: 2015 Jan 22.
Published in final edited form as: J Am Chem Soc. 2014 Jan 9;136(3):822–825. doi: 10.1021/ja4086726

Figure 4.

Figure 4

The mechanism of coupled folding and binding is concentration dependent. The mechanism of interconversion between U and FL2 was assessed by calculating the fractional flux through each of 18 pathways. Species populations (spheres) and fractional fluxes (path lines) were calculated for 2.5 µM protein and the indicated pyrophosphate concentrations using parameter values derived from the global best-fit of TMAO- and PPi-induced folding stopped-flow data. The populations and fluxes were calculated using. A movie version of this figure is available as a .qt file.

HHS Vulnerability Disclosure