Table 1.
Lesion-Psychiatric Correlates after Pediatric TBI
| Disorder | Lesion Correlate (timing of outcome) | Source |
|---|---|---|
| Novel Psychiatric Disorder | Lower fractional anisotropy in bilateral frontal, temporal lobes, uncinate fasiculi, centrum semiovale (3 months) | [12] |
| Personality Change due to TBI | Superior frontal gyrus (6 and 12 months) | [10, 43] |
| Frontal white matter (24 months) | [43] | |
| ADHD | Right putamen, thalamus (12 months) | [20, 51] |
| Orbital frontal gyrus (6 months) | [46] | |
| PTSD (re-experiencing criterion) | Right limbic area (including cingulum, hippocampus) lower lesion fraction (12 months) | [63] |
| PTSD (hyperarousal symptoms) | Left temporal lesions and lower frequency of orbitofrontal lesions (12 months) | [64] |
| Obsessions | Mesial prefrontal and temporal (12 months) | [67] |
| Obsessive Compulsive Disorder | Frontal and temporal lobe (3-9 months) | [66] |
| Anxiety Disorder/subclinical anxiety disorder | Superior frontal gyrus (6 months) Lower frequency of orbitofrontal lesions (12 months) | [64, 68] |
| Non-Anxious Depressive Disorder/subclinical depressive disorder | Left inferior frontal gyrus and left temporal tip (6 months) | [72] |
| Anxious Depressive disorder/subclinical depressive disorder | Right frontal lobe white matter and left parietal lobe (6 months) | [72] |
| Mania/Hypomania | Frontal lobe and temporal lobe (3-24 months) | [70] |