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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Mar 16;21(4):397–404. doi: 10.1038/nsmb.2795

Figure 6. Modeled structure of the entire IgE molecule in different biological contexts.

Figure 6

On the right in each panel, the allowed range of locations for each Fab arm is represented by a sphere (blue or yellow for each Fab) placed at the center of the allergen binding site. Cartoon (a) and schematic (b) depictions of acutely and rigidly bent IgE bound to FcεRIα (purple). IgE (chain A in dark and light blue, chain B in dark and light orange), and FcεRIα (purple) are shown. Cartoon (c) and schematic (d) depictions of membrane bent IgE as part of the BCR. The extra membrane-proximal domains of mIgE are indicated by a circle (in c) and a black spacer bar (in d), since their structure is unknown. Igα/β, the BCR accessory proteins, are shown in c (green). Cartoon (e) and schematic (f) depictions of extended IgE conformations as part of the BCR. Igα/β, the BCR accessory proteins, are shown in e (green).