Skip to main content
. Author manuscript; available in PMC: 2014 Apr 7.
Published in final edited form as: Endocrinology. 2012 Nov 2;153(12):5896–5905. doi: 10.1210/en.2012-1481

Figure 3. Effects of 11β-HSD2 deficiency on blood pressure, vascular remodelling and neointimal lesion formation.

Figure 3

A) 11β-HSD2−/− mice had substantially higher systolic blood pressure, measured by tail cuff plethysmography, than age-matched C57Bl/6J mice.

B) Uninjured femoral arteries showed medial hypertrophy and outward remodelling resulting in a larger total vessel area.

C) Following intra-arterial injury neointimal lesion area was not different between groups. Representative sections stained with United States Trichrome are shown as insets (scale bar = 100 μm); arrows indicate internal and external elastic laminae.

Data are mean±SEM for n= 6/group and were analysed by unpaired Student’s t-tests. ns indicates non-significant, * indicates p<0.05, ** indicates p<0.01.