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. Author manuscript; available in PMC: 2014 Apr 7.
Published in final edited form as: Endocrinology. 2012 Nov 2;153(12):5896–5905. doi: 10.1210/en.2012-1481

Figure 4. Effects of the MR antagonist eplerenone on neointimal lesions in C57Bl/6J mice and 11β-HSD2−/− mice.

Figure 4

A) Eplerenone had no effect on systolic blood pressure in either normotensive C57Bl/6J or hypertensive 11β-HSD2−/− mice (p=0.6).

B) Eplerenone reduced neointimal area in both C57Bl/6J and 11β-HSD2−/− mice.

C) Eplerenone reduced macrophage content of lesions (staining for Mac-2), but did not affect smooth muscle (α-smooth muscle actin staining) or collagen (Picrosirius red) content.

Data are mean±SEM for n= 6/group and were analysed by two-way ANOVA and post hoc t tests when appropriate. ns indicates non-significant, ** indicates p<0.01.