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. Author manuscript; available in PMC: 2014 Apr 7.
Published in final edited form as: Endocrinology. 2012 Nov 2;153(12):5896–5905. doi: 10.1210/en.2012-1481

Figure 5. Effects of 11β-HSD1 inhibition/deletion on neointimal lesion formation in C57Bl/6J mice.

Figure 5

A) In mice on a C57Bl/6J background, neointimal lesions were similar in 11β-HSD1−/− mice and wild type controls, and were not significantly affected by compound 544. Representative sections stained with United States Trichrome are shown as insets (scale bar = 100 μm); arrows indicate internal and external elastic laminae.

B) 11β-HSD1 inhibition did not affect macrophage (staining for Mac-2), collagen (Picrosirius red) or smooth muscle (α-smooth muscle actin staining) content of lesions.

Data are mean±SEM for n= 6/group and were analysed by un-paired Student’s t-tests. ns indicates non-significant.