Table 1. Effects of corticosteroid manipulation on body weights.
| Intervention | Time point* | Body Weight (g) | p | |
|---|---|---|---|---|
| Controls | Intervention | |||
| Systemic dexamethasone | Baseline | 26.6±0.6 | 25.8±0.4 | 0.3 |
| 4-weeks | 28.5±0.5 | 25.3±0.3 | <0.0001 | |
| Local cortisol | Baseline | 28.8±1.1 | 27.8±1.9 | 0.7 |
| 4-weeks | 29.3±1.0 | 28.1±1.6 | 0.5 | |
| Adrenalectomy | Baseline | 30.0±0.8 | 29.4±0.6 | 0.6 |
| 4-weeks | 28.4±0.5 | 28.2±0.5 | 0.7 | |
| GR antagonism (RU38486) | Baseline | 28.8±1.1 | 28.7±0.7 | 0.9 |
| 4-weeks | 29.3±1.0 | 29.2±0.6 | 0.9 | |
| MR antagonism (eplerenone) | Baseline | 29.3±0.7 | 28.5±0.5 | 0.4 |
| 4-weeks | 30.9±1.0 | 29.0±0.7 | 0.2 | |
| 11β-HSD2 deletion in C57Bl/6J | Baseline | 29.3±0.7 | 28.7±0.4 | 0.5 |
| 4-weeks | 29.3±1.0 | 28.1±0.6 | 0.3 | |
| 11β-HSD1 deletion in C57Bl/6J | Baseline | 29.5±0.7 | 30.0±0.4 | 0.5 |
| 4-weeks | 30.0±0.5 | 30.7±0.8 | 0.5 | |
| 11β-HSD1 inhibition in C56Bl/6J | Baseline | 29.0±0.7 | 29.1±0.5 | 0.9 |
| 4-weeks | 29.1±0.9 | 28.5±0.4 | 0.5 | |
| 11β-HSD1 deletion in Apo-E−/− | Baseline | 29.9±0.9 | 26.2±0.4 | <0.01 |
| 4-week | 32.8±0.4 | 28.6±0.5 | <0.001 | |
| 11β-HSD1 inhibition in Apo-E−/− | Baseline | 30.2±0.5 | 30.1±0.5 | 0.9 |
| 4-weeks | 30.4±0.7 | 28.6±0.5 | 0.05 | |
*
Baseline weights were measured one week before angioplasty and terminal weights 3 weeks after angioplasty
GR, Glucocorticoid receptor; MR, Mineralocorticoid Receptor; 11β-HSD, 11beta-hydroxy steroid dehydrogenase; ApoE−/−, apolipoprotein E knockout mice. Date represent Mean ± SEM, for n= 6-8 mice / group.