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. Author manuscript; available in PMC: 2014 Apr 7.
Published in final edited form as: Nat Neurosci. 2013 Jul 21;16(9):1211–1218. doi: 10.1038/nn.3469

Figure 1. A switch from an M1 to an M2-dominant microglia/macrophage response occurs at the initiation of remyelination.

Figure 1

(a) Oligodendroglial lineage cell responses in the corpus callosum at 3, 10, and 21 days post lesion (dpl) induction by stereotactic injection of lysolecithin (LPC). (b) Lesions immunostained against iNOS (green), Arg-1 (red), and CD68 (white) at 3, 10 and 21 dpl. Inset: isotype controls. Scale bar, 25 μm. (c) Percentage of iNOS+ M1 cells, Arg-1+ M2 cells, and iNOS-Arg-1-(unpolarized) cells per field in lesion ± s.e.m.. One way ANOVA and Newman-Keuls post-hoc test, ***p<0.001 (n=5 mice, df=44).