Table 5.
Effect of lipid composition and PEG-lipid on entrapment efficiency and release profile of FLX loaded liposomes
| Formulation | Lipid composition | EE% | Stability at 37 °C | %DR1h | %DR6h | %DR24h | %DR48h |
|---|---|---|---|---|---|---|---|
| F7 | EPC:Chol:PEG 70:25:5 |
77.3 ± 1.4 | 72 h | 13.5 ± 1.3 | 31.1 ± 1.4 | 34.6 ± 1.5 | 52.5 ± 3.2 |
| F8 | DMPC:Chol:PEG 70:25:5 |
63.3 ± 1.6 | 96 h | 42.1 ± 2.8 | 53.1 ± 1.1 | 55.2 ± 1.2 | 69.3 ± 4.4 |
| F9 | DPPC:Chol:PEG 70:25:5 |
51.7 ± 1.2 | 96 h | 27.5 ± 0.1 | 61.4 ± 7.6 | 70.1 ± 1.1 | 76.9 ± 4.3 |
| F10 | DSPC:Chol:PEG 70:25:5 |
83.0 ± 3.4 | 216 h | 8.1 ± 0.1 | 15.9 ± 0.2 | 16.6 ± 0.1 | 20.2 ± 0.5 |