Figure 4.

Seizure-induced increase in instantaneous firing frequency (IFF) was reversed by paxilline application. IFF was measured as the reciprocal of interval between the first and the second AP during 200 pA current injection. IFF significantly increased during acute phase of pilocarpine-induced seizure. After bath application of paxilline, IFF returned to sham levels. Data were shown as mean ± SEM (N = 6 in each group).

*p<0.05, **p<0.01 significant difference compared to sham group.

+p<0.05, ++p<0.01 significant difference compared to acute seizure group.