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. Author manuscript; available in PMC: 2015 Mar 27.
Published in final edited form as: Cell. 2014 Mar 27;157(1):142–150. doi: 10.1016/j.cell.2014.02.032

Figure 2. One possible mechanism for the influence of the virome on host phenotype.

Figure 2

Since the virome differs between individuals, and since multiple sensors of viral infection can induce overlapping but distinct transcriptional effects, the virome of asymptomatic individuals may play an important role in regulating the transcriptional state of healthy people. This transcriptional state is referred to as the immunophenotype of the host in the text. Individuals may then respond to triggers of disease in different ways in a manner dependent on the nature of their individual viromes and genetic constitution.