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. 2013 Nov 30;35(4):784–794. doi: 10.1093/carcin/bgt390

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© The Author 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 5. — WNT5A stimulates aerobic glycolysis via the activation of Akt signalling. (A) A2058 cells treated with rWNT5A for 30–90min have increased phospho-Akt (p-Akt) levels compared with carrier-treated cells, as determined by immunoblotting. Example experiment of 5 is shown. (B) Inhibition of rWNT5A-mediated increase in lactate secretion in A2058 cells by MK-2206 (an allosteric Akt-1, -2 and -3 inhibitor) treatment. N = 3. (C) Inhibition of rWNT5A-mediated increase in lactate secretion in A2058 cells by rapamycin (mTOR complex-1 inhibitor) treatment. N = 3.