Table 1.

Characteristics of the patients with small cell bladder carcinoma and large cell neuroendocrine carcinoma of bladder.

ID	Age/Sex	Smoking/drinking*	Major co-morbidities	Presenting symptom(s)	Family history	Prior cancer	Stage at diagnosis	Histology	Primary treatment	OS (m)	Status
1	67/M	Y/N	Coronary artery disease, myocardial infarction	Dysuria	Prostate cancer in brother and cousin	No	II	Pure small cell	Radical surgery	84	Alive
2	80/F	Y/N	Hypertension	Frequency, dysuria, Hematuria	No	No	II after neoadjuvant therapy	Small cell and high grade urothelial carcinoma	Neoadjuvant 4 cycle of Ca/E, then radical surgery	48	Dead
3	62/M	Y/Y	Depression	Hematuria	No	No	II	Small cell and high grade papillary urothelial carcinoma	NA	36	Alive
4	85/F	N/N	Stroke, myocardial infarction, hypertension, dementia	Renal failure	Colon cancer in son	Breast cancer	II	Pure Lc NEc#	TURBT then concurrent chemoradiation	36	Dead
5	80/M	Y/N	Coronary artery disease, diabetes, hypertension, hypothyroidism	Difficulty in urination	Lung cancer in mother	No	II	Primary Lc NEc,# papillary urothelial carcinoma	Radical surgery	25	Dead
6	70/M	Y/Y	Depression	Diagnosed on surveillance cystoscopy	None	TCCb, prostate cancer	II	Pure Lc NEc	Neoadjuvant 3 cycles of Ci/G, then radical surgery then 1 cycle of Ci/G	17	Alive
7°	78/F	Y/N	Coronary artery disease, myocardial infarction, atrial fibrillation, hypertension, hypothyroidism, depression	Hematuria	Breast cancer in 2 daughters	No	II	Pure small cell	Concurrent chemoradiation	7	Dead
8	84/F	N/N	Hypertension, hypothyroidism	Hematuria	Lung in father	Breast	III	Small cell and squamous differentiation	Radical surgery	108	Alive
9	69/M	Y/N	Hypertension	Hematuria	Kidney in father	No	III	Small cell and high grade urothelial carcinoma	Radical surgery	26	Dead
10	55/F	Y/N	None	Left neck mass	Cancer in brother	No	IV	Small cell in primary and large cell neuroendocrine carcinoma in metastasis	Neoadjuvant 5 cycles of Ci/E, then radical surgery, then adjuvant 2 cycles of Ci/E	30	Dead
11	89/M	Y/N	Dementia	Hematuria	No	No	IV	Small cell and adenocarcinoma	Partial cystectomy	12	Dead
12	69/M	Y/N	Diabetes	Back pain	Gastric in mother	No	IV	Small cell and Lc NEc	4 cycle of Ca/E, then radiation	10	Dead
13	67/F	N/N	Congestive heart failure, diabetes, hypothyroidism	Hematuria/frequency, then pain	Unknown Cancer in mother; prostate cancer in brother	No	IV	Pure small cell	Chemotherapy, then RT which was prematurely stopped	8	Dead
14	36/F	Y/N	Asthma	Hematuria	Lung cancer in father and grandmother; leukemia in aunt	No	IV	Pure Lc NEc#	Radical surgery, then Ci/E	8	Dead
15	77/M	Y/N	Coronary artery disease, atrial fibrillation, hypertension, aortic aneurysm	Hematuria	No	No	IV	Small cell bladder carcinoma and prostate adenocarcinoma	Radical surgery	7	Dead
16	78/F	N/N	Hypertension	Urgency, frequency	No	No	IV	Small cell and non-papillary urothelial carcinoma	Radical surgery	6	Dead
17	78/F	Y/N	Hypertension, hypothyroidism, transient ischemic attack	Hematuria	Gastric in mother	No	IV	Pure small cell	Radical surgery	5	Dead
18	84/F	Y/N	Depression and hypertension	Hematuria	No	Rectal	IV	Small cell and urothelial carcinoma in situl cycle of chemo, then hospice		2	Dead

OS, overall survival; Ca/E, Carboplatin/Etoposide chemotherapy; yr, Year; m, Month; Lc NEc, Large cell neuroendocrine carcinoma; TURBT, Transurethral resection of bladder tumor; TCCb, transitional cell carcinoma of bladder; Ci/G, Cisplatin/Gemcitabine chemotherapy; Ci/E, Cisplatin/Etoposide chemotherapy; NA not available.

*Smoking status was defined as no for never-smoker and yes for ever-smoker. Social drinking was considered as no drinking.

°Cancer cells showed multiple copies of chromosomes 3, 7 and 17.

^#The primary cancer in these patients was large cell neuroendocrine carcinoma.