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Functional interactions of AD-related proteins. Functions and interactions for ten proteins previously reported to be abnormal in brains from patients with AD converge on NMDAR activity and phosphorylation of Tau. See text for references. Arrows, activation or phosphorylation; blunt lines, inhibition or dephosphorylation; dashed lines, interaction. Yellow, changed in NL only; blue, changed in NL+M only; green, changed in both NL and in NL+M; stripes in any color, changed in M.
