. Author manuscript; available in PMC: 2014 Apr 7.

Published in final edited form as: Clin Cancer Res. 2011 Oct 5;18(1):256–262. doi: 10.1158/1078-0432.CCR-11-1633

Table 2. Scientific productivity for phase III trials, excluding trials closed less than 7 years without a principal publication to date (n = 20).

	Phase III trials, n (%)

	All N = 218	Therapeutic n = 167	Nontherapeutic n = 51
Resulted in principal publication	172 (79)	135 (81)	37 (73)
Answered intended scientific question	159 (73)	125 (75)	34 (67)
Positive results	62 (39)	52 (42)	10 (29)
Negative results	97 (61)	73 (58)	24 (71)
Inconclusive	13 (6)	10 (6)	3 (6)
Closed ≥ 7 years without a principal publication	46 (21)	32 (19)	14 (27)