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Buffer dependence of the observed binding enthalpies, intrinsic binding enthalpies and the number of linked protons for the neomycin binding with poly(dA).2poly (dT) triplex in 10 mM buffer, 0.5 mM EDTA and 100 mM KCl; pH 6.8, T= 10 °C.
| Drug | Buffer | ΔHobs (kcal/mol) |
ΔHion (kcal/mol) |
ΔHint (kcal/mol) |
Δn (per drug) |
|---|---|---|---|---|---|
| Neomycin | cacodylate | − 7.4 ±0.1 | −0.19 | − 7.3 ±0.1 | 0.23 ± 0.06 |
| Neomycin | MOPS | −6.2 ±0.1 | +5.07 | − 7.3 ±0.1 | 0.23 ± 0.06 |
