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. 2014 Feb 24;111(13):4940–4945. doi: 10.1073/pnas.1316013111

Fig. 3.

Fig. 3.

Oral MG+ suppresses ADAM10 expression and increases Aβ in brain. Data are from 18-mo C57BL6 mice fed an MG+ or MG− diet and Reg mice (24–26 mo, n = 8/group). (A) Western blots of brain extracts for ADAM10, APP, and soluble or sAPPβ (n = 3–5). β-actin is used as control. (B, i) Densitometry of ADAM10 protein data shown in A and (B, ii) of ADAM10 mRNA levels, by RT-PCR, shown as AU (n = 5/group). (C) Densitometry of sAPPβ and APP shown in A and expressed as sAPPβ/APP ratio. (D) Aβ1–42 levels. Data in B–D are shown as percent (mean ± SEM) of Reg. *P < 0.05 MG+ vs. MG− mice.