. 2014 Feb 24;111(13):4940–4945. doi: 10.1073/pnas.1316013111

Table 1.

Mice characteristics

Groups	MG⁻	MG⁺	Reg
Number/group	12 (6 F/6 M)	12 (6 F/6 M)	8 (4 F/4 M)
Body weight (g)	30.8 ± 0.52	35.1 ± 1.8^*	33.5 ± 1.5
Brain weight (g)	0.48 ± 0.1	0.46 ± 0.05	0.48 ± 0.1
Brain/body weight ratio	0.017 ± 0.004^†	0.013 ± 0.001^*	0.014 ± 0.003
Food intake (g/d)	4.8 ± 0.8	4.9 ± 0.05	5 ± 0.7
Food MG intake (nmol/d)	0.67 × 10^4†	1.9 × 10^4‡	1.5 × 10⁴
Serum CML (sCML, U/mL)	21.9 ± 1.2^§	49.9 ± 1.1^‡	42.8 ± 1.5
Serum MG (sMG, nmol/mL)	0.83 ± 0.2^†	2.08 ± 0.29^‡,¶	1.59 ± 0.2
Fasting blood glucose (mg/dL)	82.6 ± 2.8	81.4 ± 4	83.1 ± 2.4
Fasting insulin (nmol/L)	0.24 ± 0.02^§	0.41 ± 0.07^*	0.45 ± 0.02
Adiponectin (μg/mL)	13.7 ± 1.2^†	7.8 ± 1.0^‡	8.2 ± 0.4
Leptin (ng/mL)	10.3 ± 0.9^†	22.7 ± 0.9^‡	18.0 ± 0.8
8-Isoprostane (pg/mL)	88 ± 5.5^†	267 ± 32.4^‡,¶	174 ± 22.3
Brain protein CML (U/g brain)	100.3 ± 12.2	166.3 ± 19.4^*	142.6 ± 10
Brain protein MG (nmol/g brain)	63.4 ± 6.3	90.1 ± 11.05^*	78.4 ± 6.5
Brain lipid CML (U/g brain)	229.5 ± 15.5	352.5 ± 39.2^*	290.4 ± 14.3
Brain lipid MG (nmol/g brain)	6.3 ± 1.3	10.0 ± 0.6^*	7.5 ± 0.5

Mice were WT C57BL6. MG⁻ denotes 18-mo mice on low-AGE diet. MG⁺ denotes 18-mo mice on a MG-supplemented low-AGE diet. Reg denotes 24- to 26-mo control mice on standard NIH-31 open formula diet. Data are means ± SEM. *P < 0.05 and ^‡P < 0.01 between MG⁺ and MG⁻ mice; ^¶P < 0.05 between MG⁺ and Reg mice; ^†P < 0.05 and ^§P < 0.01 between MG⁻ and Reg mice.