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. 2014 Mar 17;111(13):E1274–E1283. doi: 10.1073/pnas.1312112111

Fig. 5.

Fig. 5.

Transgenic expression of Nxph1 has no effect on basal synaptic transmission. (A) Sample traces of glutamatergic mEPSCs recorded from cortical layer 5 neurons of WT (Upper trace) and Nxph1-GFPtg/- (Lower trace) mice. (B) Cumulative distribution and averaged (Inset) frequency of mEPSCs is not altered at transgenic synapses (WT, gray; Nxph1-GFPtg/−, red). Similarly, peak amplitudes (C) and decay time constants (D) were not different. Data are means ± SEM (collected from 17 WT cells from eight animals and 10 cells from seven mice of Nxph1-GFPtg/−). n.s., not significant. (E) Sample traces of inhibitory minis (mIPSCs). (F) Cumulative frequency and average (Inset) of mIPSCs is not altered at Nxph1-GFPtg/- synapses, which is similar to amplitudes (G) and decay time constants (H) of mIPSCs. Data are means ± SEM (collected from 19 WT cells from 6 mice and 34 Nxph1-GFPtg/− cells from 11 mice). n.s., not significant.