Fig. 2.

Ultrastructural localization of pS214-tau in dendritic spines in monkey dlPFC. (A and B) In aged spines, p-tau (arrowheads) aggregates directly over the postsynaptic membrane of asymmetric, presumed glutamatergic synapses (black arrows and Insets); bracket in A, Inset denotes an asynaptic adherens junction for comparison. Symmetric synapses onto spines, as in synaptic triads, were not labeled (B, white arrows). (C–E) In addition to the selective accumulation at asymmetric spine synapses, p-tau in aged dlPFC aggregates over the SA (asterisk). Note that the limiting membrane of the apparatus reticular cisterns is labeled, as is the spine postsynaptic membrane in E (double arrowheads). Ax, axon; Sp, spine. (Scale bars: 200 nm.)