Fig. 1.

Golgi is fragmented in APPswe/PS1∆E9 transgenic mice. (A and B) Fluorescence images of the Golgi in neurons of APPswe/PS1∆E9 transgenic mice. Cryostat sections of hippocampal tissues from 12-mo-old transgenic (B) and WT mice (A) were immunostained for TGN38. (C–F) EM micrographs of the Golgi region in neurons of APPswe/PS1∆E9 transgenic mice. Shown are EM images from ultrathin sections of hippocampal (C and D) and cortical (E and F) tissues from 12-mo-old transgenic mice (D and F) and WT mice (C and E).