. 2014 Mar 20;111(13):4745–4746. doi: 10.1073/pnas.1401955111

Table 1.

Summary of the cell of origin experiments

Study	Oncogenic drivers	Initiation method	Location of tumors	Tumor lineage markers	Probable cell of origin
2	K-Ras^LSLG12V	Polr2a-CreERT2 +4OHT	Alveoli: adenoma Bronchioles, BADJ: hyperplasia	Alv: SPC Bron/BADJ: SPC, CC10, CC10/SPC	Alv: AT2 cell Bron/BADJ: club cell/BASC
2	K-Ras^LSLG12V	Adeno-Cre	Alveoli: ademona, adencarcinoma Bronchioles, BADJ: hyperplasia, adenoma	Alv: SPC Bron/BADJ: SPC, CC10, CC10/SPC	Alv: AT2 cell Bron/BADJ: club cell/BASC
2	K-Ras^LSLG12V	Sca-1-Cre	Bronchioles: hyperplasia, adenoma	CC10, CC10/SPC	Club cell precursor
2	K-Ras^LSLG12V	Sca-1-CreERT2 +4OHT	Alveoli: adenoma	SPC	AT2 cell
3	K-Ras^LSLG12D	Adeno SPC-Cre	Alveolar hyperplasia	SPC	AT2 cell
3	K-Ras^LSLG12D	Adeno CC10-Cre	BADJ papilloma	CC10, SPC, CC10/SPC	Club cell/BASC
3	K-Ras^LSLG12D Trp53^fl/fl	Adeno SPC-Cre	Alveoli adenoma, adencarcinoma	Not shown	AT2 cell
3	K-Ras^LSLG12D Trp53^fl/fl	Adeno CC10-Cre	BADJ papillary carcinoma	Not shown	Club cell/BASC

Summary of the different initiation methods and oncogenic drivers used by Mainardi et al. (2) and Sutherland et al. (3). The location, histological description, and lineage markers of the resulting tumors, as well as the probable cell(s) of origin that can be inferred from these data are also shown. Alv, alveolar; Bron, bronchiolar.