Table 2.
Kaplan-Meier estimated proportion of patients still able to work and still able to live independently after baseline visit, stratified by age at baseline and disease duration
| Proportion of patients still able to work or live independently (95% CI) | ||||
|---|---|---|---|---|
|
| ||||
| Time after baseline visit | Age ≤70, Disease duration ≤4 years | Age ≤70, Disease duration >4 years | Age >70, Disease duration ≤4 years | Age >70, Disease duration >4 years |
| Ability to work | N=108 | N=60 | N=85 | N=50 |
| 1 year | 99% (97% - 100%) | 95% (89% - 100%) | 95% (91% - 100%) | 89% (80% - 99%) |
| 2 years | 97% (94% - 100%) | 88% (79% - 97%) | 90% (83% - 97%) | 79% (68% - 92%) |
| 3 years | 94% (89% - 99%) | 82% (73% - 93%) | 77% (68% - 87%) | 61% (48% - 78%) |
| 4 years | 91% (86% - 97%) | 72% (61% - 85%) | 70% (60% - 81%) | 56% (42% - 74%) |
| 5 years | 88% (81% - 95%) | 66% (55% - 80%) | 58% (47% - 71%) | 43% (30% - 63%) |
| 6 years | 82% (74% - 91%) | 58% (46% - 73%) | 52% (41% - 66%) | 27% (16% - 48%) |
| 8 years | 64% (52% - 77%) | 38% (26% - 55%) | 35% (24% - 50%) | 14% (6% - 33%) |
| 10 years | 44% (28% - 59%) | 26% (15% - 44%) | 8% (3% - 23%) | 3% (1% - 23%) |
| Ability to live independently | N=129 | N=111 | N=129 | N=122 |
| 1 year | 100% (97% - 100%) | 97% (94% - 100%) | 98% (95% - 100%) | 92% (87% - 97%) |
| 2 years | 98% (96% - 100%) | 91% (85% - 97%) | 95% (91% - 99%) | 85% (79% - 93%) |
| 3 years | 95% (91% - 99%) | 88% (82% - 95%) | 90% (85% - 96%) | 78% (70% - 87%) |
| 4 years | 92% (87% - 98%) | 78% (69% - 87%) | 88% (81% - 95%) | 67% (57% - 78%) |
| 5 years | 90% (84% - 96%) | 68% (58% - 79%) | 80% (72% - 90%) | 57% (47% - 70%) |
| 6 years | 87% (80% - 94%) | 65% (55% - 76%) | 76% (67% - 87%) | 41% (30% - 56%) |
| 8 years | 83% (75% - 92%) | 49% (38% - 64%) | 58% (45% - 74%) | 27% (17% - 43%) |
| 10 years | 64% (50% - 83%) | 31% (20% - 49%) | 23% (12% - 46%) | 5% (1% - 20%) |
• The patient cohort consisted of 495 patients either able to work at baseline or able to live independently at baseline. Kaplan-Meier estimates for loss of ability to work were evaluated for the 303 patients who were able to work at baseline. Kaplan-Meier estimates for loss of ability to live independently at baseline were evaluated for the 491 patients who were able to live independently at baseline. Patients were stratified into four different age and disease duration groups based on the median value of each measure, in order to provide meaningful Kaplan-Meier estimates for specific patient groups.