Table 3.
Associations of baseline demographic and disease information with loss of ability to work and loss of ability to live independently
| Association with loss of ability to work (N=303) | Association with loss of ability to live independently (N=491) | |||
|---|---|---|---|---|
|
| ||||
| Variable | Estimated RR (95% CI) | P-value | Estimated RR (95% CI) | P-value |
| Gender (Male) | 1.08 (0.78 – 1.50) | 0.64 | 1.09 (0.79 – 1.51) | 0.60 |
| Personal history of depression | 0.92 (0.66 – 1.29) | 0.64 | 1.21 (0.88 – 1.68) | 0.25 |
| Current depression | 0.83 (0.51 – 1.35) | 0.45 | 1.10 (0.68 – 1.78) | 0.70 |
| Family history of movement disorders | 1.06 (0.74 – 1.50) | 0.77 | 0.87 (0.61 – 1.24) | 0.44 |
| Family history of PD | 0.84 (0.53 – 1.31) | 0.44 | 0.87 (0.56 – 1.34) | 0.52 |
| Intellectual impairment | 3.58 (1.53 – 8.41) | 0.0033 | 3.55 (2.14 – 5.98) | 1×10-5 |
| Hoehn and Yahr stage (>2) | 2.05 (1.34 – 3.13) | 0.0009 | 1.99 (1.42 – 2.80) | 7×10-5 |
| ADL score (any impairment) | 2.30 (1.20 – 4.41) | 0.012 | 2.13 (1.47 – 4.11) | 8×10-5 |
| UPDRS – tremor (5 point increase) | 1.06 (0.76 – 1.48) | 0.72 | 0.89 (0.66 – 1.18) | 0.41 |
| UPDRS – rigidity (5 point increase) | 1.37 (1.07 – 1.74) | 0.012 | 1.26 (1.02 – 1.55) | 0.033 |
| UPDRS – bradykinesia (10 point increase) | 1.40 (1.09 – 1.81) | 0.0094 | 1.38 (1.13 – 1.70) | 0.0019 |
| UPDRS – instability (3 point increase) | 2.04 (1.54 – 2.69) | 6×10-7 | 1.73 (1.43 – 2.09) | 2×10-8 |
| UPDRS – dyskinesia (>0) | 1.87 (1.19 – 2.93) | 0.0067 | 2.39 (1.61 – 3.57) | 2×10-5 |
| UPDRS – total (20 point increase) | 1.60 (1.19 – 2.15) | 0.0017 | 1.44 (1.14 – 1.82) | 0.0019 |
• Estimated relative risks and p-values result from Cox proportional hazards models adjusted for age and disease duration. Relative risks correspond to presence of the given characteristic or the increase given in parenthesis. P-values ≤ 0.0033 were considered statistically significant after a Bonferroni adjustment for the 15 statistical tests of association that were performed for each endpoint. The patient cohort consisted of 495 patients either able to work at baseline or able to live independently at baseline. Associations with loss of ability to work were evaluated for the 303 patients who were able to work at baseline. Associations with loss of ability to live independently at baseline were evaluated for the 491 patients who were able to live independently at baseline. PD, Parkinson’s disease; UPDRS, Unified Parkinson’s Disease Rating Scale.