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. 2014 Apr 1;5(2):e01107-13. doi: 10.1128/mBio.01107-13

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Copyright © 2014 Al-Mulla et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 1 — Genetic characteristics of MHV mutants. The schematic shows amino acid changes responsible for temperature-sensitive phenotypes of viruses used in this study. Amino acid positions are numbered from the start of each nonstructural protein. Functions of potentially affected domains that are marked include papain-like proteinases (PL1^pro and PL2^pro), ADP-ribose 1ʺ phosphatase (ADRP), main proteinase (M^pro), RNA-dependent RNA polymerase (RdRp), and methyltransferases (N7-MT and 2O-MT).