Table 2.
Mutational points found in the polymyxin-resistant determinants among the 14 polymyxin-resistant A. baumannii isolates as compared to susceptible isolates.
| Isolate | Mutations | |||
|---|---|---|---|---|
| pmrA | lpxD | lpxC | lpsB | |
| AC12 | P102H | S102T, V141I, and R173G | K141R | H181Y |
| AC30 | P102H | S102T, V141I, and R173G | K141R | H181Y |
| AC3 | P102H | T104K, I178V | S158R | — |
| AC13 | P102H | T121A, N151D, and G169S | S158R | — |
| AC16 | P102H | E50D, V141I | K141R | H181Y |
| AC17 | P102H | E50D, V141I | K141R | H181Y |
| AC18 | P102H | E50D, V141I | K141R | H181Y |
| AC20 | P102H | T15A, T121A, N151D, and G186S | K141R, S158R | H181Y |
| AC21 | P102H | T15A, T121A, N151D, and G186S | K141R, S158R | — |
| AC22 | P102H | E50D, S102T, and I178V | K141R, S158R | H181Y |
| AC27 | P102H | S102T, G169S, and R173G | S158R | H181Y |
| AC38 | P102H | S102T, G169S, I178V, and G186S, | K141R | — |
| AC51 | P102H | E50D, R173G | K141R, S158R | — |
| AC61 | P102H | I178V, S181N | K141R, S158R | — |
∗Note: no mutation was detected in pmrC, pmrB, and lpxA.