Table 2.
The genotyping results of SNPs in IL-6 and IL-6R.
| Gene | Position | Rs No. | Allele/genotype | TB (n, %) | Control (n, %) | OR | P | Bonf P |
|---|---|---|---|---|---|---|---|---|
| IL6 | 5 near | rs17147230 | A | 334, 47.3 | 388, 48.7 | 0.94 [0.77–1.56] | 0.58 | 5.79 |
| T | 372, 52.7 | 408, 51.3 | ||||||
| AA | 83, 23.5 | 94, 23.6 | 0.67 | 6.70 | ||||
| TA | 168, 47.6 | 200, 50.2 | ||||||
| TT | 102, 28.9 | 104, 26.1 | ||||||
| Promoter | rs1800796 | G | 243, 33.7 | 269, 34.4 | 1.03 [0.83–1.28] | 0.77 | 7.72 | |
| C | 463, 66.3 | 529, 65.6 | ||||||
| GG | 43, 12.2 | 49, 12.3 | 0.90 | 9.00 | ||||
| GC | 157, 44.5 | 171, 42.9 | ||||||
| CC | 153, 43.3 | 179, 44.9 | ||||||
|
| ||||||||
| IL-6R | Promoter | rs3887104 | A | 65, 9.4 | 56, 7.2 | 1.33 [0.92–1.93] | 0.13 | 1.34 |
| G | 629, 90.6 | 720, 92.8 | ||||||
| AA | 3, 0.9 | 0, 0 | 0.06 | 0.63 | ||||
| AG | 59, 17.0 | 56, 4.4 | ||||||
| GG | 285, 82.1 | 332, 85.6 | ||||||
| 5 UTR | rs4845617 | A | 370, 47.4 | 322, 48.6 | 0.95 [0.77–1.17] | 0.65 | 6.48 | |
| G | 358, 52.6 | 392, 51.4 | ||||||
| AA | 78, 22.9 | 90, 23.6 | 0.87 | 8.70 | ||||
| AG | 166, 48.8 | 190, 49.9 | ||||||
| GG | 96, 28.2 | 101, 26.5 | ||||||
| Intron | rs7411976 | C | 39, 5.6 | 34, 4.4 | 1.27 [0.79–2.04] | 0.32 | 3.19 | |
| A | 661, 94.4 | 732, 95.6 | ||||||
| CC | 2, 0.6 | 0, 0 | 0.20 | 2.00 | ||||
| CA | 35, 10 | 34, 8.9 | ||||||
| AA | 313, 89.4 | 349, 91.1 | ||||||
| Intron | rs4845618 | G | 320, 46.1 | 342, 44.0 | 1.09 [0.89–1.34] | 0.41 | 4.08 | |
| T | 374, 53.9 | 436, 56.0 | ||||||
| GG | 77, 22.2 | 73, 18.8 | 0.51 | 5.10 | ||||
| GT | 166, 47.8 | 196, 50.4 | ||||||
| TT | 104, 30 | 120, 30.9 | ||||||
| Intron | rs4845626 | T | 57, 8.1 | 71, 8.9 | 0.90 [0.63–1.30] | 0.58 | 5.78 | |
| G | 649, 92.9 | 729, 91.1 | ||||||
| TT | 4, 1.1 | 1, 0.2 | 0.15 | 1.50 | ||||
| TG | 49, 13.9 | 69, 17.2 | ||||||
| GG | 300, 85.0 | 330, 82.5 | ||||||
| Missense | rs2228145 | C | 290, 41.7 | 350, 46.5 | 0.82 [0.67–1.01] | 0.06 | 0.62 | |
| A | 406, 58.3 | 402, 53.5 | ||||||
| CC | 60, 17.2 | 81, 21.5 | 0.17 | 1.70 | ||||
| CA | 170, 48.9 | 188, 50.0 | ||||||
| AA | 118, 33.9 | 107, 28.5 | ||||||
| 3 UTR | rs2229238 | T | 46, 6.5 | 87, 10.9 | 0.57 [0.39–0.83] | 0.003 | 0.03 | |
| C | 660, 93.5 | 711, 89.1 | ||||||
| TT | 2, 0.6 | 2, 0.5 | 0.004 | 0.04 | ||||
| TC | 42, 11.9 | 83, 20.8 | ||||||
| CC | 309, 87.5 | 314, 78.7 | ||||||
| 3 UTR | rs3828078 | A | 43, 6.1 | 34, 4.3 | 1.46 [0.92–2.31] | 0.11 | 1.08 | |
| G | 663, 93.9 | 764, 95.7 | ||||||
| AA | 0, 0 | 2, 0.5 | 0.03 | 0.29 | ||||
| AG | 43, 12.2 | 30, 7.5 | ||||||
| GG | 310, 87.8 | 367, 92.0 | ||||||
Logistic regression analyses were used for calculating OR (95% CI: confidence interval). Value was determined by Fisher's exact test.