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The catalytic domains of mariner DNA transposases and retroviral integrases adopt a common Rnase-H like fold. Catalytic core domain structures of (a) Mos1 transposase (PDB ID: 2F7T), (b) SETMAR transposase domain (PDB ID: 3K9J), (c) HIV-1 integrase (PDB ID: 1BIS), and (d) PFV Integrase in the intasome complex (PDB ID: 3S3M). Residues of the DDD/N or DDE active site triads are labeled, along with the coordinated metal ions and conserved Tyr and Pro residues.
