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Thermal stability of Mos1 transposase. (a) Mos1 transposase is stabilized by MgCl2 and MnCl2. The melting temperature (Tm) and standard deviations (s.d.) were calculated as the mean of three measurements. The chemical structures of (b) Raltegravir and (c) Elvitegravir from http://www.chemspider.com. (d) Effect of increasing Raltegravir or Elvitegravir concentrations on the Tm of Mos1 transposase. Reactions contained 20 mM MgCl2 or MnCl2 as indicated.
