Figure 6.

Raltegravir inhibits Mos1 strand transfer. (a) Schematic of the strand transfer assay. (b) Denaturing polyacrylamide gel showing the effect of increasing concentrations of Raltegravir on strand transfer activity of Mos1 transposase. Lane 1 shows oligonucleotide markers of length indicated to the left of the lane. The control reaction in lane 2 did not contain Mos1 transposase. (c) Graph of intensity of the product bands as a function of Raltegravir concentration (band intensities are normalized to the intensity of the 40 nt product without Raltegravir).