Table 2. Effects of Incubation of Tafamidis ex Vivo on Subunit Exchange Kinetic Parameters in Human Plasmaa.
| [tafamidis] (μM) | kex (h–1) | SE kexb | t1/2c (days) | change in kexd (%) |
|---|---|---|---|---|
| 0e | 8.91 × 10–3 | 2.93 × 10–4 | 3.24 | – |
| 5 | 4.29 × 10–3 | 1.23 × 10–4 | 6.73 | –51.8 |
| 10 | 2.31 × 10–3 | 6.37 × 10–5 | 12.52 | –74.1 |
| 20 | 1.12 × 10–3 | 4.12 × 10–5 | 25.71 | –87.4 |
| 30 | 5.98 × 10–4 | 3.10 × 10–5 | 48.31 | –93.3 |
a
Subunit exchange rates and half-times, as well as the change in subunit exchange rates relative to vehicle control, were calculated from the data presented in Figure 4D.
b
SE kex is the standard error of kex.
c
t1/2 is the time needed for the subunit exchange reaction to reach a fraction exchange of 0.5.
d
The change in kex is calculated relative to the vehicle control as [(kex of interest) – (kex of vehicle)]/(kex of vehicle) × 100.
e
The DMSO vehicle control is 0 μM tafamidis.