Table 2. Distance Criteria Used in Defining Specific Interactions between Drug and hERG Model Pore Residues in Low Energy Score Docked Poses.

interaction	distance criteria
parallel π–π	ring centers within 4.5 Å
T-shaped π–π	aromatic H – ring center distance within 4 Å
cation-π	protonated N or adjacent CH within 4 Å of aromatic ring center
H-bond	OH-X or NH-X within 2.5 Å (X is H-bond acceptor)
cation in K+ site	protonated N atom within 3 Å of cavity K+ site