TABLE 2.
Means and SD of Fractional Anisotropy (x1000) in Fiber Bundles
| HC (n=55) M (SD) |
CUD (n=31) M (SD) |
CHR (n=21) M (SD) |
EOS (n=55) M (SD) |
F (df=3, 162) | |
|---|---|---|---|---|---|
| Fiber Tract | |||||
| L. cingulum | 456 (34) | 480 (29) | 458 (38) | 459 (35) | |
| R. cingulum | 441 (32) | 451 (30) | 438 (34) | 445 (26) | |
| L. superior longitudinal fasciculus | 468 (29) | 468 (22) | 458 (21) | 464 (23) | |
| R. superior longitudinal fasciculus | 472 (32) | 470 (29) | 462 (29) | 466 (27) | |
| L. corticospinal | 599 (24) | 599 (25) | 583 (25)a,b | 581 (29)a,b | 5.80** |
| R. corticospinal | 590 (23) | 587 (19) | 570 (28)a,b | 576 (26)a,b | 6.26*** |
| L. inferior longitudinal fasciculus | 480 (24) | 474 (24) | 462 (27)a,b | 463 (26)a | 4.62** |
| R. inferior longitudinal fasciculus | 486 (30) | 476 (26) | 476 (24) | 473 (27) | |
| L. inferior fronto-occipital fasciculus | 529 (25) | 522 (22)a | 511 (23)a | 513 (26)a | 5.77** |
| R. inferior fronto-occipital fasciculus | 534 (22) | 530 (23) | 523 (24) | 524 (29) | |
| L. uncinate | 382 (36) | 383 (30) | 376 (24) | 384 (22) | |
| R. uncinate | 410 (26) | 415 (28) | 405 (29) | 411 (28) |
Note: Multivariate tests (Wilk’s lambda): Wide Range Achievement Test (WRAT) score32: F=1.22, p=.21; Sex: F=1.05, p=.41; Age: F=1.33, p=.21; Positive urine analysis for cannabis: F=1.15, p=.32. CHR=clinical high-risk for schizophrenia; EOS=earlyonset schizophrenia, with and without comorbid cannabis use disorder (CUD); L=left; R=right.
a
Significant difference from healthy controls (HC): p<.05.
b
Significant difference from CUD: p<.05.
**
p<.01;
***
p<.001