Table 4.

Spearman Rho Correlations Between Fiber Tract and Neurocognitive Measures in Early-Onset Schizophrenia (EOS)

	L. inferior longitudinal fasciculus	L. inferior fronto-occipital fasciculus	L. corticospinal	R. corticospinal
Hypothesized to be significant relationships
Number-letter switchinga (n=54)	.28*		.23
Grooved pegboardb, dominant hand (n=54)	−.05	−.19
Exploratory relationships
CVLTc long delay free recall (n=54)	.22	.11	−.14	.05
CPTd d-prime 4 (n=54)	.31	.21	−.17	−.09
20 questions achievement scoree (n=54)	.40**	.32	.05	.09
Category switching correct responsese (n=54)	.37**	.38**	.004	−.02
Cannon-Spoor premorbid adjustment24 (n=53)	−.30	−.29	−.15	−.13
WRATf score (n=54)	−.10	.11	−.26	−.31
Lifetime CPZg exposure (n=55)	−.07	.09	.22	.04
Current CPZg exposure (n=55)	.03	−.11	.20	.29

Note: EOS with and without comorbid cannabis use disorder (CUD); L=left; R=right.

^aSubtest of trail-making test in Delis-Kaplan Executive Function System (D-KEFS)³³

^bGrooved Pegboard Test³⁵

^cCalifornia Verbal Learning Test (CVLT)³⁴,⁵⁷

^dContinuous Performance Test³⁶

^eSubtest of D-KEFS³³

^fWide Range Achievement Test (WRAT)³²

^gChlorpromazine (CPZ) equivalents²⁵

^*p<.05

^**p<.01